The coach from Casilda (Argentina), who had led the Chilean national team to its first official title (Copa América 2015), arrived at the club in the summer of 2016 with the challenge of replacing the laureate Unai Emery. Under him, the team finished the league championship in fourth place, collecting a total of 72 points, and reached the last 16 of the Champions League. He left the club a year after his arrival to coach the Argentina national team.
The Argentine coach returned to the Sevilla bench several years later, in October 2022, replacing Julen Lopetegui as first-team coach. Despite qualifying for the quarter-finals of the UEFA Europa League, he was unable to lead Sevilla out of the bottom half of the league table, and was eventually replaced by José Luis Mendilibar in March 2023.