For the 2019/2020 season, Julen Lopetegui was the coach chosen to lead Sevilla FC's new project from the bench under the guidance of Monchi in his return to the sporting general management role. After his time with FC Porto, the Spanish national team and Real Madrid, the Basque coach takes the reins of a completely revamped squad, after an intense summer in which 13 signings were made.
During his first season at the helm in Nervión, Sevilla FC finished the league championship in fourth position, qualifying directly for the next edition of the UEFA Champions League. In addition to this brilliant achievement, the Basque coach would shortly after win the sixth UEFA Europa League for Sevilla FC, after beating Inter Milan (3-2) in the final in Cologne. That victory, as well as qualifying Sevilla FC for the FIFA Club World Cup, was a record for the Nervión club, as it capped a successful run of 21 matches unbeaten in a single season.
During his second season on the Sevilla bench, in 2020/21, the Basque coach would continue to set new records for the club. The pandemic caused by COVID-19 and the consequent disruption to the football calendar forced Sevilla FC to link the end of the previous campaign with the start of the new season, with practically no interruption and only a few days' holiday for the first team players. Thus, at the end of September, Sevilla FC faced Bayern Munich in the final of the European Super Cup, a German team against whom they competed at a very high level and who could only overcome Sevilla FC by the slimmest of margins in extra time (2-1). Despite this defeat, Lopetegui's side had a brilliant season, culminating in a fourth-place finish in the league and thus securing a place in the following edition of the Champions League, which was secured with five games to spare.
In the Spanish Cup, Lopetegui led his side to the semi-finals, where they fell agonisingly to FC Barcelona, who forced extra time in the last minute of the second leg in Barcelona. In the Champions League, after reaching the round of 16, Sevilla FC faced Borussia Dortmund. A narrow defeat in Nervión (2-3) and a draw on German soil (2-2) eliminated them from the competition. The overall season, however, produced a really positive outcome for Lopetegui and his team, as the brilliant fourth place in La Liga was followed by a series of records of enormous merit in that competition, including the season with the highest number of points (77), the season with the highest number of victories (24) and the season with the highest number of consecutive matches undefeated (18).
In his third season in charge of the Sevilla first team, the coach from Guipuzcoa achieved an unprecedented milestone in the club's history, qualifying for the next year's Champions League for the third time in a row directly through the league, a competition in which he achieved a creditable fourth place. In other words, Sevilla FC achieved a European qualification for the eighteenth time in the last 19 seasons. During the Basque coach's third season at Nervión, Sevilla FC also managed to finish the league championship as the team that had conceded the fewest goals in the league, a record that had only been achieved once before (1950/51 season) and which, together with his great performances, earned Yassine Bono the first Zamora Trophy in the history of the club.
His time as Sevilla FC coach came to an end at the beginning of October 2022, after a series of poor results in what was already his fourth season at Nervión. His name, however, was forever inscribed in golden letters in the club's history, having brilliantly won a European title, the UEFA Europa League in the 2019/20 season. In addition to this, there were milestones such as the three consecutive league qualifications for the Champions League, the record points tally in the Primera División and the fact that, under his guidance, Sevilla FC were the team that conceded the fewest goals in the 2021/22 league championship, with Yassine Bono winning the Zamora Trophy.
In total, the coach managed Sevilla on 170 occasions: 121 matches in the First Division, 15 in the Spanish Cup, 16 in the UEFA Europa League, 17 in the Champions League and one in the European Super Cup, with a record of 89 wins, 45 draws and 36 defeats.