Following the sacking of Marcelino García Toral in the middle of the 2011/12 season, Sevilla FC appointed Míchel as the Asturian's replacement at the helm of the club's first team. The Madrid-born coach remained in charge until midway through the following season, when after a poor first half of the season, which left the team in twelfth position with just 22 points, he was sacked and replaced by Unai Emery.

The Asturian coach took charge of the Sevilla FC first team at the start of the 2011/12 season. After a run of more than two months without a win, taking just five points from 21 in La Liga, Marcelino was sacked on 6 February 2012, having previously lost in the last 16 of the Copa del Rey and in the UEFA Europa League qualifying round.

He joined Sevilla to replace Antonio Álvarez at the end of September 2010. For the rest of the 2010/11 season in charge of the first team, Goyo Manzano managed to finish fifth in the league championship, losing in the Copa del Rey and UEFA Europa League to Real Madrid and Porto, clubs that would go on to become champions of those competitions.

Following the departure of José Antonio Camacho, Antonio Álvarez was appointed to take charge of the Sevilla squad, on an interim basis, until the arrival of Carlos Salvador Bilardo. During this first period, Álvarez was in charge of the team for just one matchday, the 23rd of the 1996/1997 season, when they lost to Real Zaragoza by two goals to one at La Romareda.

After this short-lived first spell, Álvarez returned to the Sevilla bench at the end of the 2009/10 season, replacing Manolo Jiménez. Thus, the club's sporting management showed their confidence in a local man, who had previously acquired enormous experience as assistant coach to Joaquín Caparrós and Juande Ramos, among others. During the ten league games that remained to be played, Álvarez managed to lift the team from fifth to fourth place, thus qualifying them for the qualifying round of the next edition of the Champions League. The icing on the cake was the Copa del Rey, for which the club had already reached the final under Jiménez.

The successes achieved at the end of the 09/10 season earned the coach his continuity at the helm of the team for the following season. However, defeat against FC Barcelona in the final of the Spanish Super Cup, together with elimination at the hands of Sporting Braga in the Champions League qualifiers and a shaky start to the league campaign, led to the dismissal of the coach at the end of September 2010, and he was replaced by Gregorio Manzano.

Former Sevilla international Manolo Jiménez took over as first team coach after Juande Ramos' departure in October 2007 from Sevilla Atlético, the club he was managing at the time. During his first season, he managed to straighten out a team that was languishing in mid-table, leaving them in fifth place. In the following season, 2008/09, despite the departure of important players and an early elimination from European competition, Jiménez managed to get the team to third place, reaching the semi-finals of the Spanish Cup.

Jiménez would hold the position of Sevilla coach until March 2010, when, after a series of matches without a win, he was dismissed from his post. By then, however, he had managed to qualify the team for the final of the Spanish Cup, which would eventually be won by the Nervión club under his replacement Antonio Álvarez.

The La Mancha-born coach joined the Nervión outfit at the start of the 2005/06 season to replace Caparrós, and remained in charge of the first team until the end of October 2007, when he decided to leave the club by terminating his contract with mutual consent.

During his successful tenure, Sevilla FC won the UEFA Cup twice (2006 and 2007), won the European Super Cup (2006), won the Spanish Cup and Super Cup (2007) and was named Best Club in the World by the IFFHS in 2006 and 2007. Under his guidance, Sevilla FC fought for the league title in 06/07 until the last matchday. He is the most successful coach in the history of Sevilla FC.

The Utrera-born coach arrived at Sevilla under the guidance of the then president Roberto Alés and his sporting director, Ramón Rodríguez Verdejo, Monchi, at the beginning of the 2000/01 season, with the sole objective of attempting the all-out challenge to reach the First Division. During his first season in charge of the first team, Caparrós achieved the long-awaited promotion, winning the Second Division title by a landslide.

Over the next four seasons in the Sevilla dugout, the Utrera native not only managed to secure Sevilla's place in the top flight, but also to qualify for the UEFA Cup on two occasions. It was the second of these, achieved at the end of his last season at the club, that would lead to the club's first European silverware a year later.

Almost 13 years after his departure, Caparrós returned to the club in April 2018 following the sacking of Vincenzo Montella. With just three games left in the season plus the postponed match against Real Madrid, the Utrerano's mission was to qualify the team for the UEFA Europa League. He even did so with a game to spare, managing three wins and a draw. At the end of the season, it was announced that he would move into the office as the club's director of football.

In March 2019, he began his third spell in charge of the Sevilla bench following the dismissal of Pablo Machín, leaving his post as the club's Director of Football. With a balance of six wins, one draw and four defeats in the last eleven league games, he tied for sixth place, which allowed Sevilla FC to qualify directly for the group stage of the UEFA Europa League.

The Santander-born coach arrived at Nervión in January 1999 to replace Fernando Castro Santos at the helm of the Sevilla FC first team, when they were hovering around the mid-table positions. Under Marcos Alonso, Sevilla enjoyed an excellent second half of the season, which ended with a dramatic match in Malaga, where a victory would give the club the chance to play for promotion to the First Division against Villarreal. That memorable match would mean Sevilla FC's return to the top flight.

Marcos Alonso's tenure as coach of the Nervion side came to an end in March 2000, after the 27th matchday of the league season, when the Sevillian side were at the bottom of the table and practically doomed to relegation. His replacement was Juan Carlos Álvarez, who took charge of the Sevilla bench for the third time.

Backed by his experience of promotion with Compostela, Fernando Castro Santos arrived in Seville in January 1998 to take over from Juan Carlos Álvarez at the helm of the Sevilla first team. After an unsuccessful first attempt to achieve promotion to the Spanish top flight, Castro Santos was sacked in the middle of the following season, 1998/99, and replaced by Marcos Alonso.

The Cantabrian took over as Sevilla first team coach from Julián Rubio after the sixth matchday of the 1997/98 Second Division championship. His appointment, however, did not achieve the expected reaction from the Nervion side, and so, after a brief period at the club, he was sacked and replaced by Juan Carlos Álvarez.