It wasn't our night. After taking four points from six in the last two away matches, we were beaten on our return to the Ramón Sánchez-Pizjuán.
An Atlético Madrid team filled with star names was unable to fully control the tie but did enough to take the points, with a first-half goal from Marcos Llorente and a second-half strike by Morata, just when it seemed as though Sevilla were going to react strongly in the second half.
Although it was Atlético who had the first goal-scoring opportunity of the match, with a cross that Bono managed to deal with conceding the corner, it was another energetic start to the match which saw Sevilla come out looking to turn the tide in the tie and get a goal against Atleti.
At times the squad seemed to defend well, with Isco on song in the centre of the park and Kasper Dolberg showing glimpses of quality, although perhaps not in the best position to make the most of his chances.
Atlético, as we've seen so often, waited for mistakes and capitalised on them, as they made life difficult for Bono and the defenders.
Lopetegui's squad tried to exploit the right-hand side of the park with José Ángel's speed and the driving runs forward of Lamela, who tried switching wings with Óliver in search of an opening.
Morata had the first chance with 20 minutes on the clock but, with the goal gaping, he fired over the bar. Things got more complicated in the 28th minute with an injury to Rekik who had to be withdrawn for Telles.
After the substitution, Atleti would score, as Llorente finished a cross to make it 1-0. It was critical minutes for Sevilla as they saw Morata miss another guilt-edged chance.
Sevilla regained some control of the game as Atleti dropped back a bit. Sevilla struggled to make chances, however, as Oblak only had to worry about one header from Dolberg.
Atleti scored in the first half and killed the game off in the second
Lopetegui brought on Rakitić and Navas after half-time and Sevilla did improve. The first 15 minutes of the second half were played almost exclusively in Atlético's half. The shot, however, was lacking.
Gudelj tried a shot from range in the 58th minute but it veered wide. Morata's next shot would not veer wide as he lifted it over Bono, making the most of good pressure from Cunha.
It was a tough blow for Sevilla who watched on as their errors cost them. Cunha had a big chance soon after, but Bono came out with a big save.
Simeone's men were in control of the match, sitting back and waiting for the counter. Lopetegui tried to change things by bringing on Papu and En-Nesyri who partnered Dolberg in attack.
The biggest chance came for the Moroccan striker who headed a powerful effort at goal and forced Oblak into a good save.
A tough defeat for the team after some positive showings away from home. Football never stops, however, and we are back in action in the Champions League as we welcome Dortmund to Sevilla on Wednesday night.